Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.7
USERS' SCORE
Good
Based on 6 Reviews
8.3
Supplement Facts
Serving Size: 3 Soft Gels
Amount Per Serving
%DV
Calories
35
Total Fat
3 g
4%
Saturated Fat
0.5 g
3%
Trans Fat
0 g
†
Cholesterol
15 mg
5%
Vitamin A
30 mcg RAE
3%
Total Omega-3s
750 mg
†
EPA (Eicosapentaenoic Acid)
240 mg
†
DHA (Docosahexaenoic Acid)
360 mg
†
Other Omega-3s
150 mg
†
Top Medical Research Studies
9
We investigated the effects of cod liver oil, rich in omega-3 fatty acids, on heart health following a heart attack in rats. After a feeding period, we discovered that cod liver oil significantly boosted the heart's ability to withstand fibrillation and reduced abnormal heart rhythms.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
Read More
9
We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Read More
9
DHA aids post-heart attack recovery
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Read More
Most Useful Reviews
9
Asthma relief
5 people found this helpful
My daughter's asthma symptoms improved remarkably after two weeks of taking cod liver oil. Prior to this, she experienced severe coughing and had to be rushed to the hospital. Now, she only has occasional flare-ups. I appreciate Nordic Naturals for their high processing standards and safety for children.
Read More
9
Cholesterol improvement
1 people found this helpful
I bought cod liver oil for my mother to manage her cholesterol. After three months, her levels normalised, reducing inflammation and heart attack risks. The taste is acceptable, and it has good Omega-3 content, suitable for the elderly.
Read More
7.5
Improved heart health
6 people found this helpful
Taking these soft gel tablets has greatly aided my cholesterol levels and heart health, preventing heart attacks. I've noticed improvements in inflammation and my asthma symptoms, and my hair has thickened. The absence of a fishy taste makes them easy to swallow. I take 2-3 daily after breakfast.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.7
- All Researches
9
We aimed to investigate the impact of docosahexaenoic acid (DHA), a key component of cod liver oil, on heart damage after a heart attack. Using laboratory models, we observed that DHA helps improve heart cell survival and function after cardiac injury.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
Read More
9
We investigated the effects of cod liver oil, rich in omega-3 fatty acids, on heart health following a heart attack in rats. After a feeding period, we discovered that cod liver oil significantly boosted the heart's ability to withstand fibrillation and reduced abnormal heart rhythms.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
It improved heart functioning during rest, but we found no significant impact on heart pressure or contraction speed. While there are some promising signs, the overall influence of cod liver oil on heart attack recovery remains limited.
Read More
9
We examined the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on the risk of heart attacks through a comprehensive analysis of the VITAL trial. This significant study included nearly 26,000 older adults in the U.S. who were monitored over an average of 5.3 years.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
Read More
9
We explored the role of eicosapentaenoic acid (EPA) in heart attack recovery, particularly its effect on restoring blood flow during ST-elevation myocardial infarction (STEMI). Our focus was on understanding whether higher levels of EPA relative to arachidonic acid could lead to faster recovery and better outcomes for patients experiencing this type of heart attack.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
Read More
9
We explored how eicosapentaenoic acid (EPA) and its metabolites can protect heart cells during a heart attack, specifically focusing on a laboratory model for ischemic injury. Our investigation centered on a specific receptor found in heart cells, known as the Free Fatty Acid Receptor 4 (Ffar4).
In our experiments, cardiac myocytes, or heart cells, were exposed to a controlled environment mimicking conditions of reduced blood flow followed by reoxygenation, essentially simulating a heart attack scenario. Applying an Ffar4 agonist, TUG-891, along with EPA-derived components like 18-hydroxyeicosapentaenoic acid (18-HEPE) and resolvin E1 (RvE1), we observed a significant reduction in harmful reactive oxygen species and heart cell death.
Notably, blocking the ChemR23 receptor with a specific antagonist negated the protective effects we noted from these treatments. This finding highlights that Ffar4 and ChemR23 work together in heart cells to defend against the damage that occurs after ischemic injury.
Overall, our data reinforce the idea that eicosapentaenoic acid has beneficial roles in protecting heart cells from ischemia, meriting further exploration as a potential therapeutic in heart attack management.
In our experiments, cardiac myocytes, or heart cells, were exposed to a controlled environment mimicking conditions of reduced blood flow followed by reoxygenation, essentially simulating a heart attack scenario. Applying an Ffar4 agonist, TUG-891, along with EPA-derived components like 18-hydroxyeicosapentaenoic acid (18-HEPE) and resolvin E1 (RvE1), we observed a significant reduction in harmful reactive oxygen species and heart cell death.
Notably, blocking the ChemR23 receptor with a specific antagonist negated the protective effects we noted from these treatments. This finding highlights that Ffar4 and ChemR23 work together in heart cells to defend against the damage that occurs after ischemic injury.
Overall, our data reinforce the idea that eicosapentaenoic acid has beneficial roles in protecting heart cells from ischemia, meriting further exploration as a potential therapeutic in heart attack management.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Asthma relief
5 people found this helpful
My daughter's asthma symptoms improved remarkably after two weeks of taking cod liver oil. Prior to this, she experienced severe coughing and had to be rushed to the hospital. Now, she only has occasional flare-ups. I appreciate Nordic Naturals for their high processing standards and safety for children.
Read More
9
Cholesterol improvement
1 people found this helpful
I bought cod liver oil for my mother to manage her cholesterol. After three months, her levels normalised, reducing inflammation and heart attack risks. The taste is acceptable, and it has good Omega-3 content, suitable for the elderly.
Read More
7.5
Improved heart health
6 people found this helpful
Taking these soft gel tablets has greatly aided my cholesterol levels and heart health, preventing heart attacks. I've noticed improvements in inflammation and my asthma symptoms, and my hair has thickened. The absence of a fishy taste makes them easy to swallow. I take 2-3 daily after breakfast.
Read More
7.5
Cholesterol reduction
1 people found this helpful
The quality of this cod liver oil is excellent, and I find the lemon flavour pleasant. After three weeks of use, I noticed significant improvements in heart function and lower cholesterol levels, which helps in reducing heart attack risks.
Read More
7.5
Heart benefits
1 people found this helpful
This pure Arctic Cod Liver Oil is an excellent and natural source of Omega-3. It is easy to swallow and helps with heart function and regulating blood pressure, thereby reducing the risk of heart attacks.
Read More
Frequently Asked Questions
7.5
Cholesterol reduction
1 people found this helpful
The quality of this cod liver oil is excellent, and I find the lemon flavour pleasant. After three weeks of use, I noticed significant improvements in heart function and lower cholesterol levels, which helps in reducing heart attack risks.
9
Cholesterol improvement
1 people found this helpful
I bought cod liver oil for my mother to manage her cholesterol. After three months, her levels normalised, reducing inflammation and heart attack risks. The taste is acceptable, and it has good Omega-3 content, suitable for the elderly.
9
Asthma relief
5 people found this helpful
My daughter's asthma symptoms improved remarkably after two weeks of taking cod liver oil. Prior to this, she experienced severe coughing and had to be rushed to the hospital. Now, she only has occasional flare-ups. I appreciate Nordic Naturals for their high processing standards and safety for children.
7.5
Improved heart health
6 people found this helpful
Taking these soft gel tablets has greatly aided my cholesterol levels and heart health, preventing heart attacks. I've noticed improvements in inflammation and my asthma symptoms, and my hair has thickened. The absence of a fishy taste makes them easy to swallow. I take 2-3 daily after breakfast.
7.5
Heart benefits
1 people found this helpful
This pure Arctic Cod Liver Oil is an excellent and natural source of Omega-3. It is easy to swallow and helps with heart function and regulating blood pressure, thereby reducing the risk of heart attacks.
9
We aimed to investigate the impact of docosahexaenoic acid (DHA), a key component of cod liver oil, on heart damage after a heart attack. Using laboratory models, we observed that DHA helps improve heart cell survival and function after cardiac injury.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
Notably, DHA reduces damage, enhances heart performance, and promotes beneficial autophagy processes. It operates via specific cellular pathways. Our findings suggest DHA may offer protective benefits for the heart following a heart attack.
9
Significant heart attack risk reduction
In this extensive study involving nearly 5,800 patients with atherosclerotic cardiovascular disease (ASCVD) and high triglyceride levels, we explored the effectiveness of icosapent ethyl, a form of eicosapentaenoic acid, in reducing the risk of major adverse cardiovascular events (MACE) like heart attacks.
Patients were randomly assigned to receive either icosapent ethyl or a placebo, with their health monitored over a median follow-up of nearly five years. The results were promising: we noticed a significant reduction in MACE in the group receiving icosapent ethyl compared to those on placebo.
Specifically, there were 361 instances of MACE in the icosapent ethyl group versus 489 in the placebo group. This translates to a 28% lower risk of events like heart attacks or strokes for those taking icosapent ethyl. Furthermore, we observed that the absolute benefits were greatest for patients with higher baseline cardiovascular risk.
Overall, regardless of their initial risk levels, using icosapent ethyl showed an impressive potential to decrease the risk of major cardiovascular issues, including heart attacks. This study underscores the value of incorporating eicosapentaenoic acid into treatment plans for patients at risk of heart disease.
Patients were randomly assigned to receive either icosapent ethyl or a placebo, with their health monitored over a median follow-up of nearly five years. The results were promising: we noticed a significant reduction in MACE in the group receiving icosapent ethyl compared to those on placebo.
Specifically, there were 361 instances of MACE in the icosapent ethyl group versus 489 in the placebo group. This translates to a 28% lower risk of events like heart attacks or strokes for those taking icosapent ethyl. Furthermore, we observed that the absolute benefits were greatest for patients with higher baseline cardiovascular risk.
Overall, regardless of their initial risk levels, using icosapent ethyl showed an impressive potential to decrease the risk of major cardiovascular issues, including heart attacks. This study underscores the value of incorporating eicosapentaenoic acid into treatment plans for patients at risk of heart disease.
4
We conducted a two-arm, open-label, placebo-controlled study to evaluate the effectiveness of cod liver oil in preventing heart attacks among patients at risk for cardiovascular events. Over a span of three years, we enrolled 870 participants who provided informed consent to be part of this important research.
The study group received a daily supplement of 415 mg of cod liver oil alongside their standard treatment, while a control group received no additional treatment. We followed both groups for 12 months, monitoring them closely for any developments of myocardial infarction (MI).
Our findings showed that those who took cod liver oil experienced slightly fewer instances of heart attacks; however, this difference wasn’t statistically significant, with a p-value of 0.09. This means we didn't find compelling evidence that cod liver oil effectively reduces the risk of heart attacks, both fatal and non-fatal.
Given these results, it's clear that while we explored the potential benefits of cod liver oil, more extensive studies are necessary to confirm its true role in heart health and preventing cardiovascular events.
The study group received a daily supplement of 415 mg of cod liver oil alongside their standard treatment, while a control group received no additional treatment. We followed both groups for 12 months, monitoring them closely for any developments of myocardial infarction (MI).
Our findings showed that those who took cod liver oil experienced slightly fewer instances of heart attacks; however, this difference wasn’t statistically significant, with a p-value of 0.09. This means we didn't find compelling evidence that cod liver oil effectively reduces the risk of heart attacks, both fatal and non-fatal.
Given these results, it's clear that while we explored the potential benefits of cod liver oil, more extensive studies are necessary to confirm its true role in heart health and preventing cardiovascular events.
9
We examined the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on the risk of heart attacks through a comprehensive analysis of the VITAL trial. This significant study included nearly 26,000 older adults in the U.S. who were monitored over an average of 5.3 years.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
References
- Shi Y, Li H, Wu T, Wang Q, Zhu Q, et al. Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway. Oxid Med Cell Longev. 2022;2022:1509421. doi:10.1155/2022/1509421
- Nilsen DWT, Myhre PL, Kalstad A, Schmidt EB, Arnesen H, et al. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction. Nutrients. 2021;13. doi:10.3390/nu13103475
- Mal M, Kumar A, Meraj A, Devi A, Mañego AMB, et al. Role of Cod Liver Oil in Preventing Myocardial Infarction. Cureus. 2021;13:e16067. doi:10.7759/cureus.16067
- Meerson FZ, Belkina LM, Fu STs, Isaev VA. [Correction of disorders of cardiac electric stability in post-infarction cardiosclerosis using a diet enriched with polyunsaturated fatty acids]. Biull Eksp Biol Med. 1993;115:343.
- Skúladóttir GV, Gudmundsdóttir E, Olafsdóttir E, Gudmundsson TV, Hardarson T, et al. Influence of dietary cod liver oil on fatty acid composition of plasma lipids in human male subjects after myocardial infarction. J Intern Med. 1990;228:563.
- Kahl PE, Schimke E, Hildebrandt R, Beitz J, Schimke I, et al. The influence of cod-liver oil diet on various lipid metabolism parameters, the thromboxane formation capacity, platelet function and the serum MDA level in patients suffering from myocardial infarction. Cor Vasa. 1987;29:199.
- Fischer S, Weber PC. Thromboxane (TX)A3 and prostaglandin (PG)I3 are formed in man after dietary eicosapentaenoic acid: identification and quantification by capillary gas chromatography-electron impact mass spectrometry. Biomed Mass Spectrom. 1985;12:470.
- Fischer S, Weber PC. Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid. Nature. 1984;307:165.
- Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.028
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. doi:10.1161/JAHA.124.038656
- Yamada R, Uematsu M, Nakamura T, Kobayashi T, Horikoshi T, et al. Elevated eicosapentaenoic acid to arachidonic acid ratio and rapid coronary blood flow restoration in ST-elevation myocardial infarction. Hellenic J Cardiol. 2025. doi:10.1016/j.hjc.2025.01.003
- Puccini SJ, Healy CL, Harsch BA, Ahmed AR, Shearer GC, et al. A Cell Autonomous Free fatty acid receptor 4 - ChemR23 Signaling Cascade Protects Cardiac Myocytes from Ischemic Injury. bioRxiv. 2025. doi:10.1101/2024.11.26.625260
- Miyauchi K, Iwata H, Nishizaki Y, Inoue T, Hirayama A, et al. Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid (RESPECT-EPA). Circulation. 2024;150:425. doi:10.1161/CIRCULATIONAHA.123.065520
- Dinu M, Sofi F, Lotti S, Colombini B, Mattioli AV, et al. Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis. Eur J Prev Cardiol. 2024;31:1863. doi:10.1093/eurjpc/zwae184
- Burger PM, Bhatt DL, Dorresteijn JAN, Koudstaal S, Mosterd A, et al. Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT. Eur Heart J Cardiovasc Pharmacother. 2024;10:488. doi:10.1093/ehjcvp/pvae030
- Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, et al. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. J Am Coll Cardiol. 2024;83:1529. doi:10.1016/j.jacc.2024.02.016
- Sabbour H, Bhatt DL, Elhenawi Y, Aljaberi A, Bennani L, et al. A Practical Approach to the Management of Residual Cardiovascular Risk: United Arab Emirates Expert Consensus Panel on the Evidence for Icosapent Ethyl and Omega-3 Fatty Acids. Cardiovasc Drugs Ther. 2024. doi:10.1007/s10557-023-07519-z
- Bernhard B, Heydari B, Abdullah S, Francis SA, Lumish H, et al. Effect of six month's treatment with omega-3 acid ethyl esters on long-term outcomes after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial. Int J Cardiol. 2024;399:131698. doi:10.1016/j.ijcard.2023.131698
- Le VT, Knight S, Watrous JD, Najhawan M, Dao K, et al. Higher docosahexaenoic acid levels lower the protective impact of eicosapentaenoic acid on long-term major cardiovascular events. Front Cardiovasc Med. 2023;10:1229130. doi:10.3389/fcvm.2023.1229130
- Myhre PL, Berge T, Kalstad AA, Tveit SH, Laake K, et al. Omega-3 fatty acid supplements and risk of atrial fibrillation and 'micro-atrial fibrillation': A secondary analysis from the OMEMI trial. Clin Nutr. 2023;42:1657. doi:10.1016/j.clnu.2023.07.002
- Borghi C, Bragagni A. Clinical results and mechanism of action of icosapent ethyl. Eur Heart J Suppl. 2023;25:B37. doi:10.1093/eurheartjsupp/suad088
- Chiusolo S, Bork CS, Gentile F, Lundbye-Christensen S, Harris WS, et al. Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J. 2023;262:38. doi:10.1016/j.ahj.2023.03.019
- Rabbat MG, Lakshmanan S, Benjamin MM, Doros G, Kinninger A, et al. Benefit of icosapent ethyl on coronary physiology assessed by computed tomography angiography fractional flow reserve: EVAPORATE-FFRCT. Eur Heart J Cardiovasc Imaging. 2023;24:866. doi:10.1093/ehjci/jead063
- Kobara M, Shiraishi T, Noda K, Toba H, Nakata T. Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats. J Cardiovasc Transl Res. 2023;16:816. doi:10.1007/s12265-023-10363-z
- Luo X, Liu M, Wang S, Chen Y, Bao X, et al. Combining metabolomics and OCT to reveal plasma metabolic profiling and biomarkers of plaque erosion and plaque rupture in STEMI patients. Int J Cardiol. 2023;390:131223. doi:10.1016/j.ijcard.2023.131223
- Bork CS, Lundbye-Christensen S, Venø SK, Lasota AN, Tjønneland A, et al. Intake of marine and plant-derived n-3 fatty acids and development of atherosclerotic cardiovascular disease in the Danish Diet, Cancer and Health cohort. Eur J Nutr. 2023;62:1389. doi:10.1007/s00394-022-03081-w
- Park GH, Cho JH, Lee D, Kim Y. Association between Seafood Intake and Cardiovascular Disease in South Korean Adults: A Community-Based Prospective Cohort Study. Nutrients. 2022;14. doi:10.3390/nu14224864
- Bassuk SS, Manson JE. Marine omega-3 fatty acid supplementation and prevention of cardiovascular disease: update on the randomized trial evidence. Cardiovasc Res. 2023;119:1297. doi:10.1093/cvr/cvac172
- Alfaddagh A, Kapoor K, Dardari ZA, Bhatt DL, Budoff MJ, et al. Omega-3 fatty acids, subclinical atherosclerosis, and cardiovascular events: Implications for primary prevention. Atherosclerosis. 2022;353:11. doi:10.1016/j.atherosclerosis.2022.06.1018
- Sunagawa Y, Katayama A, Funamoto M, Shimizu K, Shimizu S, et al. The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats. J Nutr Biochem. 2022;106:109031. doi:10.1016/j.jnutbio.2022.109031
- Halade GV, Kain V, De La Rosa X, Lindsey ML. Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure. Am J Physiol Heart Circ Physiol. 2022;322:H953. doi:10.1152/ajpheart.00684.2021
- Wang CP, Lee CC, Wu DY, Chen SY, Lee TM. Differential effects of EPA and DHA on PPARγ-mediated sympathetic innervation in infarcted rat hearts by GPR120-dependent and -independent mechanisms. J Nutr Biochem. 2022;103:108950. doi:10.1016/j.jnutbio.2022.108950
- Myhre PL, Kalstad AA, Tveit SH, Laake K, Schmidt EB, et al. Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial. J Intern Med. 2022;291:637. doi:10.1111/joim.13442
- Pertiwi K, Küpers LK, de Goede J, Zock PL, Kromhout D, et al. Dietary and Circulating Long-Chain Omega-3 Polyunsaturated Fatty Acids and Mortality Risk After Myocardial Infarction: A Long-Term Follow-Up of the Alpha Omega Cohort. J Am Heart Assoc. 2021;10:e022617. doi:10.1161/JAHA.121.022617
